Regression of established oral tumors after intralesional injection of living BCG OR BCG cell walls

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Comparison of BCG Cell Walls and Cell Wall Skeletons

BCG cell wall skeletons (SK) derived from BCG cell walls (CW) by treatment with proteolytic enzymes and organic solvents were tested for their potency to cause regression of a transplanted guinea pig hepatoma. On a weight basis, SK were as effective as CW in causing tumor regression, and they, as well as purified protein derivative of mycobacteria, provoked delayed cutaneous hypersensitivity re...

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Immunotherapy of guinea pigs with a transplanted hepatoma: comparison of intralesionally administered killed BCG cells and BCG cell walls.

Heat-killed whole BCG cells (KC) and BCG cell walls (CW) were each tested in emulsified form for their potency to cause regression of a transplanted guinea pig hepatoma. On a weight basis, KC were at least as effective as CW in causing tumor regression and elimination of microscopic lymph node metastasis, and they, as well as purified protein derivative of mycobacteria, provoked delayed cutaneo...

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Osteitis after BCG vaccination.

The authors report the case of a 21-month-old boy with an osteolytic lesion in the proximal region of the right humerus. Based on the clinical history and histological findings, the authors suspected osteitis following BCG vaccination. Symptoms remitted after antituberculosis therapy was initiated, and the patient presented radiological improvement. The authors describe this uncommon entity in ...

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Ultrastructural studies of histiocyte-tumor cell interactions during tumor regression after intralesional injection of Mycobacterium bovis.

We made an ultrastructural study of the site of a transplanted syngeneic hepatocarcinoma and its draining lymph nodes in inbred guinea pigs, in the presence and absence of Mycobacterium bovis strain Bacillus Calmette-Guérin.The bacillus was injected into the growing intradermal tumor 7 days after transplantation, at which time it had metastasized to the first regional lymph node. Critical morp...

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[Percutaneous or intradermal BCG vaccine?].

OBJECTIVE To compare the intradermal and percutaneous routes of BCG administration. SOURCES OF DATA A review of the literature published between 1987 and 2002 was carried out in the MEDLINE and Lilacs databases. The following key words were used: BCG vaccine/administration, adverse effects, efficacy, tuberculosis/prevention and control. Some articles published before 1987 were included becaus...

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ژورنال

عنوان ژورنال: Cancer

سال: 1979

ISSN: 0008-543X,1097-0142

DOI: 10.1002/1097-0142(197904)43:4<1304::aid-cncr2820430418>3.0.co;2-l